Please use this identifier to cite or link to this item:
http://repository.unizik.edu.ng/handle/123456789/299
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Esimone, Charles Okechukwu | - |
dc.contributor.author | Ihekwereme, Chibueze Peter | - |
dc.contributor.author | Nwanegbo, Edward Chieke | - |
dc.date.accessioned | 2022-11-18T11:06:20Z | - |
dc.date.available | 2022-11-18T11:06:20Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Volume 2014 | Article ID 984150 | en_US |
dc.identifier.uri | https://doi.org/10.1155/2014/984150 | - |
dc.identifier.uri | http://repository.unizik.edu.ng/handle/123456789/299 | - |
dc.description.abstract | Malaria has a negative impact on health and social and economic life of residents of endemic countries. The ultimate goals of designing new treatment for malaria are to prevent clinical infection, reduce morbidity, and decrease mortality. There are great advances in the understanding of the parasite-host interaction through studies by various scientists. In some of these studies, attempts were made to evaluate the roles of malaria pigment or toxins in the pathogenesis of malaria. Hemozoin is a key metabolite associated with severe malaria anemia (SMA), immunosuppression, and cytokine dysfunction. Targeting of this pigment may be necessary in the design of new therapeutic products against malaria. In this review, the roles of hemozoin in the morbidity and mortality of malaria are highlighted as an essential target in the quest for effective control of clinical malaria. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Advances in Pharmacological and Pharmaceutical Sciences | en_US |
dc.subject | Malaria | en_US |
dc.subject | clinical infection | en_US |
dc.subject | immunosuppression | en_US |
dc.subject | cytokine dysfunction | en_US |
dc.subject | Hemozoin | en_US |
dc.subject | pathogenesis | en_US |
dc.title | Hemozoin Inhibition and Control of Clinical Malaria | en_US |
dc.type | Article | en_US |
Appears in Collections: | Scholarly Works |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
984150.pdf | Full Text | 1.15 MB | Adobe PDF | View/Open |
Items in UnizikSpace are protected by copyright, with all rights reserved, unless otherwise indicated.