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dc.contributor.authorEsimone, Charles Okechukwu-
dc.contributor.authorIhekwereme, Chibueze Peter-
dc.contributor.authorNwanegbo, Edward Chieke-
dc.date.accessioned2022-11-18T11:06:20Z-
dc.date.available2022-11-18T11:06:20Z-
dc.date.issued2014-
dc.identifier.citationVolume 2014 | Article ID 984150en_US
dc.identifier.urihttps://doi.org/10.1155/2014/984150-
dc.identifier.urihttp://repository.unizik.edu.ng/handle/123456789/299-
dc.description.abstractMalaria has a negative impact on health and social and economic life of residents of endemic countries. The ultimate goals of designing new treatment for malaria are to prevent clinical infection, reduce morbidity, and decrease mortality. There are great advances in the understanding of the parasite-host interaction through studies by various scientists. In some of these studies, attempts were made to evaluate the roles of malaria pigment or toxins in the pathogenesis of malaria. Hemozoin is a key metabolite associated with severe malaria anemia (SMA), immunosuppression, and cytokine dysfunction. Targeting of this pigment may be necessary in the design of new therapeutic products against malaria. In this review, the roles of hemozoin in the morbidity and mortality of malaria are highlighted as an essential target in the quest for effective control of clinical malaria.en_US
dc.language.isoenen_US
dc.publisherAdvances in Pharmacological and Pharmaceutical Sciencesen_US
dc.subjectMalariaen_US
dc.subjectclinical infectionen_US
dc.subjectimmunosuppressionen_US
dc.subjectcytokine dysfunctionen_US
dc.subjectHemozoinen_US
dc.subjectpathogenesisen_US
dc.titleHemozoin Inhibition and Control of Clinical Malariaen_US
dc.typeArticleen_US
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