Department of Pharmacognosy and Traditional Medicine http://repository.unizik.edu.ng/handle/123456789/81 2025-10-12T13:29:57Z 2025-10-12T13:29:57Z Anowi, Chinedu Fredrick Obi, Patrick Ebele Obi, Chioma B Utoh – Nedosa, U. A. http://repository.unizik.edu.ng/handle/123456789/456 2023-02-12T11:25:22Z 2014-01-01T00:00:00Z

Title: Analgesic, Phytochemical and Toxicological Investigations of Ethanol Extract of the Leaves of Kigelia Africana (Lam.) Benth (Family Bignoniaceae)-Sausage Tree Authors: Anowi, Chinedu Fredrick; Obi, Patrick Ebele; Obi, Chioma B; Utoh – Nedosa, U. A. Abstract: The plant of Kigelia africana had been in use from time immemorial by the people of Ogidi in Idemili Local Government area of Anambra State, Nigeria to treat pyrexia, analgesia and infectious diseases. For example the decoction of the plant is used to treat wounds, running stomach (diarrhea), aches and pains as well as fever. This investigation was carried out to ascertain the truth of this claim. The leaves of Kigelia africana was collected and dried at ambient temperature and pulverized. Exactly 200g of the powdered drug was extracted with 400ml of ethanol using the cold maceration technique for 24 hours with occasional shaking. This was filtered and the procedure repeated with the marc. The combined filtrates were concentrated under reduced pressure with rotary evaporator. The preliminary phytochemical tests were carried out using standard methods. The analgesic was conducted using hot plate method. The acute toxicity test of the extract was determined using the Lorke’s method. The leaves of Kigelia africana exhibited analgesic property. Alkaloids, flavonoids, saponins, tannins, proteins, steroids and carbohydrates were found. Toxicity test showed that the extract was safe at the dose of 1000mg/kg.Preliminary studies support the claim that the leaves of Kigelia Africana possesses, analgesic properties. Description: Scholarly Work

2014-01-01T00:00:00Z Anowi, Chinedu Fredrick Uzodinma, S. Utoh-Nedosa, U. A. Onyegbule, Felix A http://repository.unizik.edu.ng/handle/123456789/455 2023-02-12T11:13:55Z 2014-08-01T00:00:00Z

Title: An investigation into the Anti-inflammatory Activity of n-hexane Extract of the Leaves of Baphia pubescens Hook. F (Family Leguminosae) Authors: Anowi, Chinedu Fredrick; Uzodinma, S.; Utoh-Nedosa, U. A.; Onyegbule, Felix A Abstract: Baphia pubenscens is claimed by the people of Ogidi in Idemili Local Government area of Anambra State, Nigeria to have anti pyretic, anti-inflammatory, analgesic and antimicrobial properties. The decoction of the leaves is used to treat wounds, running stomach (diarrhea), aches and pains as well as fever locally. This investigation was carried out to ascertain the veracity of these claims.The leaves of Baphia pubenscens was collected and dried at ambient temperature and pulverized. Exactly 200 g of the powdered drug was extracted with 400ml of n-hexane using the cold maceration technique for 24hours with occasional shaking. This was filtered and the procedure repeated with the marc. The combined filtrates were concentrated under reduced pressure with rotary evaporator. The preliminary phytochemical tests were carried out using standard methods. The anti-inflammatory activity was induced by egg albumin and antiinflammation measured at predetermined time after the administration of the drug.The leaves of Baphia pubescens exhibited anti-inflammatory activity by reducing the inflammation in rats. Alkaloids, flavonoids, saponins carbohydrates, carbohydrates were absent while steroids and tannins, were found. Preliminary studies support the claim that the leaves of Baphia pubennscens possess anti-inflammatory properties hence it is used by the native as anti-inflammatory agent. Description: Scholarly Work

2014-08-01T00:00:00Z Anowi, Chinedu Fredrick Ike, Chibueze Ezeokafor, Emmanuel Anikpe, Nwabunwanne Alloysius http://repository.unizik.edu.ng/handle/123456789/454 2023-02-12T10:58:23Z 2015-01-01T00:00:00Z

Title: Investigation into the anti-malarial activity of the aqueous leaf extract of Nauclea latifolia(Rubiaceae) using curative method Authors: Anowi, Chinedu Fredrick; Ike, Chibueze; Ezeokafor, Emmanuel; Anikpe, Nwabunwanne Alloysius Abstract: Malaria is a disease caused by Plasmodiumparasites that infect about 154 to 289 million people per year, resulting in approximately 660,000 – 2 million deaths worldwide. Infants, children, and pregnant females, along with immune-suppressed patients are at higher risk for worse outcomes when infected with malaria parasites. Malaria is a particular problem and a major one in areas of Asia, Africa, and Central and South America. To solve this problem, the natives of Ogidi in Anambra state of Nigeria use herbs to cure malaria and one of such herbs is Nauclea latifolia. With the rising problems of side effects, cost and limited efficacy of anti-malarial drugs, there is an urgent needfor the development of alternative anti-malarial substances and researchers are nowadays turning to natural products from plants, as their main source of bioactive compounds with anti-malarial properties to complement the existing synthetic anti-malarials that are gradually becoming less potent against pathogenic parasites. Hence, there is the need for the phytochemical screening and investigations into the anti-malarial potential of the leaves extracts of Nauclea latifoliaas it is claimed by Ogidi people to have antimalarial activity. The leaves of Nauclea latifoliawere collected and dried at ambient temperature and pulverized. Exactly 500 g of the powdered drug was extracted with 1000 ml of water using the cold maceration technique for 48hours with occasional shaking. This was filtered and the procedure repeated with the marc. The combined filtrates were concentrated under reduced pressure with rotary evaporator. The preliminary phytochemical tests were carried out using standard methods. The anti-malarial screening was conducted using the curative test (established infection) method to assess the efficacy of the extract as therapeutic agent. The following secondary metabolites were present - flavonoids, saponins, alkaloids, Carbohydrates, steroids and terpenoids. The aqueous extract exhibited complete elimination of all the parasites present (100% cure) From the research, it is found that the aqueous extract of the Nauclea latifoliais an effective anti-malarial agent as claimed by the natives of Ogidi people. Description: Scholarly Work

2015-01-01T00:00:00Z Anowi, Chinedu Fredrick Onyekaba, T. U Utoh-Nedosa, U. A. Obi, Patrick Ebele http://repository.unizik.edu.ng/handle/123456789/453 2023-02-12T10:55:10Z 2014-01-01T00:00:00Z

Title: An investigation into the antipyretic activity of n-hexane extract of the leaves of Baphia pubescens Hook.F (family Leguminosae) Authors: Anowi, Chinedu Fredrick; Onyekaba, T. U; Utoh-Nedosa, U. A.; Obi, Patrick Ebele Abstract: Baphia pubescens is claimed by the people of Ogidi in Idemili Local Government area of Anambra State, Nigeria to have anti pyretic, analgesic and antimicrobial properties. The decoction of the leaves isused to treat wounds, running stomach (diarrhea), aches and pains as well as fever locally. This investigation was carried out to ascertain the veracity of these claims. The leaves of Baphia pubescens was collected and dried at ambient temperature and pulverized. Exactly 200 g of the powdered drug was extracted with 400 ml of n-hexane using the cold maceration technique for 24hours with occasional shaking. This was filtered and the procedure repeated with the marc. The combined filtrates were concentrated under reduced pressure with rotary evaporator. The preliminary phytochemical tests were carried out using standard methods. The antipyretic activity using brewer’syeast to induce pyrexia was conducted. The leaves of Baphia pubescens exhibited antipyretic activity by lowering the temperature induced by brewer’s yeast in rats. Alkaloids, flavonoids, saponins carbohydrates, carbohydrates were absent while steroids and tannins, were found. Preliminary studies support the claim that the leaves of Baphia pubescens possess antipyretic properties Description: Scholarly Work

2014-01-01T00:00:00Z